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Träfflista för sökning "WFRF:(Olsson T) ;pers:(Hillert J);pers:(Barcellos LF)"

Search: WFRF:(Olsson T) > Hillert J > Barcellos LF

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1.	Barcellos, LF, et al. (author) Body mass index is causally associated with pediatric and adult multiple sclerosis onset: a study of over 20,000 individuals using Mendelian Randomization 2016 In: MULTIPLE SCLEROSIS JOURNAL. - 1352-4585. ; 22, s. 192-193 Conference paper (other academic/artistic)
2.	Gianfrancesco, MA, et al. (author) Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS 2017 In: Neurology. - 1526-632X. ; 88:17, s. 1623-1629 Journal article (peer-reviewed)
3.	Gianfrancesco, MA, et al. (author) Genetic risk factors for pediatric-onset multiple sclerosis 2018 In: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 24:14, s. 1825-1834 Journal article (peer-reviewed)abstract Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. Objective: We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. Methods: Cases with onset <18 years ( n = 569) and controls ( n = 16,251) were included from the United States and Sweden. Adjusted logistic regression and meta-analyses were performed for individual risk variants and a weighted genetic risk score (wGRS) for non-MHC variants. Results were compared to adult MS cases ( n = 7588). Results: HLA–DRB115:01 was strongly associated with POMS (odds ratio (OR)meta = 2.95, p < 2.0 × 10−16). Furthermore, 28 of 104 non-MHC variants studied (23%) were associated ( p < 0.05); POMS cases carried, on average, a higher burden of these 28 variants compared to adults (ORavg = 1.24 vs 1.13, respectively), though the difference was not significant. The wGRS was strongly associated with POMS (ORmeta = 2.77, 95% confidence interval: 2.33, 3.32, p < 2.0 × 10−16) and higher, on average, when compared to adult cases. Additional class III risk variants in the MHC region associated with POMS were revealed after accounting for HLA–DRB115:01 and HLA–A02. Conclusion: Pediatric and adult MS share many genetic variants suggesting similar biological processes are present. MHC variants beyond HLA–DRB115:01 and HLA–A*02 are also associated with POMS.
4.	Harroud, A, et al. (author) Locus for severity implicates CNS resilience in progression of multiple sclerosis 2023 In: Nature. - 1476-4687. ; 620619:79737969, s. 329-331 Journal article (peer-reviewed)
5.	Booth, DR, et al. (author) Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis 2010 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:6, s. 469-470 Journal article (other academic/artistic)
6.	Booth, DR, et al. (author) The expanding genetic overlap between multiple sclerosis and type I diabetes 2009 In: Genes and immunity. - : Springer Science and Business Media LLC. - 1476-5470 .- 1466-4879. ; 10:1, s. 11-14 Journal article (peer-reviewed)
7.	Esposito, F, et al. (author) IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci 2010 In: Genes and immunity. - : Springer Science and Business Media LLC. - 1476-5470 .- 1466-4879. ; 11:5, s. 397-405 Journal article (peer-reviewed)
8.	George, MF, et al. (author) Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies 2016 In: Neurology. Genetics. - 2376-7839. ; 2:4, s. e87- Journal article (peer-reviewed)
9.	Gianfrancesco, MA, et al. (author) Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility 2017 In: American journal of epidemiology. - : Oxford University Press (OUP). - 1476-6256 .- 0002-9262. ; 185:3, s. 162-171 Journal article (peer-reviewed)
10.	Rhead, B, et al. (author) Mendelian randomization provides evidence for a causal effect of low vitamin D on multiple sclerosis risk in two independent populations 2016 In: MULTIPLE SCLEROSIS JOURNAL. - 1352-4585. ; 22, s. 191-191 Conference paper (other academic/artistic)

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Result 1-10 of 11

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Type of publication: journal article (9); conference paper (2)

Type of content: peer-reviewed (8); other academic/artistic (3)

Author/Editor: Hillert, J (11)Undo refine; Olsson, T (11); Kockum, I. (11); Barcellos, LF (11)Undo refine; Alfredsson, L (9); Schaefer, C (8); show more...; Shen, L (7); Rhead, B (6); De Jager, PL (5); Harbo, HF (5); Celius, EG (5); Hauser, SL (5); Dubois, B (4); Compston, A (4); Hedstrom, A (4); Link, J (4); Goris, A (4); D'alfonso, S (4); McCauley, JL (4); Oksenberg, JR (4); Shao, X (4); Rose, J (3); Benson, L (3); Shao, XR (3); Hart, J (3); Spurkland, A (3); Saarela, J. (3); Stridh, P (3); Stefansson, K (3); Ban, M (3); Sellebjerg, F (3); Léoné, M. (3); Pericak-Vance, MA (3); Patsopoulos, NA (3); Ivinson, AJ (3); Gianfrancesco, M (3); Waldman, A (3); Lotze, T (3); Schreiner, T (3); Belman, A (3); Greenberg, B (3); Weinstock-Guttman, B (3); Aaen, G (3); Tillema, JM (3); Ness, J (3); Harris, Y (3); Rubin, J (3); Candee, M (3); Krupp, L (3); Gorman, M (3); show less...

University: Karolinska Institutet (11)

Language: English (11)

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